학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


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ǥ : ȣ - 500085   292 
Initial Treatment of Patients with Coronary Artery Disease. Data from Korean Coronary Artery Disease Registry (KCAR)
전남대병원 심장센터¹, 경희의대², 동아의대³, 영남의대⁴, 충남의대5, 충북의대6, 한림의대7
안영근¹, 정명호¹, 김종진², 조진만², 김무현³, 김영조⁴, 박종선⁴, 성인환5, 이재환5, 조명찬6, 배장환6, 한규록7
Objective: We analyzed the initial treatment of coronary artery disease, using information from the Korean Coronary Artery Disease Registry (KCAR) database. Methods and Results: Participating hospitals identify patients with a discharge diagnosis of coronary artery disease. Medical history, treatment, and outcome data are collected through review of medical records and entered into a database of KCAR. 2511 patients (mean age = 63.7±10.4 years, 1581 males) were enrolled in this study. In clinical diagnosis, 24% of patients had stable angina, 36% unstable angina, 32% acute myocardial infarction, 7% variant angina. Of patients received antiplatelet agents, 80% aspirin, 64% clopidogrel, and 21% cilostazol. The beta-blocker was treated in 58% and calcium channel blocker in 35%. Of patients, 43% received angiotensin converting enzyme (ACE) inhibitors and 15% angiotesin receptor blockers (ARB). Stains were treated in 38% of patients. Other initial drugs were nitrate (59%) , nicorandil (8%), diuretics (12%), digoxin (2%), and warfarin (1%). Percutaneous coronary intervention (PCI) was applied in 64% of patients. Almost patient (92%) underwent stent implantation in PCI patients. Average doses of drugs appeared low for ACE inhibitors, ARBs, beta-blockers, and statins with recommendation. We examined the 671 patients (894 lesion, mean age= 61.3±11.2 years, 482 males) who underwent stent implantation and follow-up coronary angiogram according to the initial medication. The patients were categorized into 4 groups; patients who received no statin and ARB (A, n=181), started statin (B, n=465, simvastatin = 20-40 mg, atorvastatin = 10-20 mg) or ARBs (C, n=54), and both statin and ARB (D, n=194) after stenting during follow-up time. ISR was lowest in group D (A, 30.3 %; B, 20.9 %; C, 19.4 %; D, 17.7 %, p<0.01). Conclusions: Combined treatment with statin and ARB could be used as a effective modality for preventing ISR in the patients with coronary artery disease. Conclusion: Initial management of patients with coronary artery disease is improving. Angiotensin receptor combined with statins are useful drugs for the prevention of in-stent restenosis.


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