Background and Objectives: We investigated whether statin therapy in patients who have coronary artery disease could influence pulse wave velocity (PWV). Subjects and Methods: Two hundred fifty-eight patients who underwent percutaneous coronary intervention and admitted for 6-month follow-up coronary angiography were selected from May 2005 to June 2007. Brachial-ankle (ba) PWV, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides (TG) at the baseline and 6 months follow-up were obtained to evaluate the effect of statin therapy in the improvement of PWV. Results: Statin was prescribed in 178 of total 258 patients at discharge. There was more reduction in LDL-cholesterol, TG, and LDL/HDL in statin group compared to non-statin group. HDL-cholesterol decreased significantly in both groups, with no significant difference (p = 0.77). We did subgroup analysis of the patients with controlled hypertension (systolic blood pressure < 140 mmHg at 6-month follow-up) to exclude the effect of blood pressure to PWV. When changes of blood pressure were adjusted, baPWV decreased more in statin group (p = 0.021). BaPWV decreased significantly as LDL/HDL decreased by 97.8m/s +/- 19.5 (vs 32.3m/s +/- 26.4, p = 0.049). Moreover, if LDL/HDL at 6-month follow-up was less than 2, baPWV also decreased significantly by 96.7 +/- 19.4 (vs 23.7 +/- 25.4, p = 0.036). Conclusions: Statin is a modest modifier of arterial stiffness of which the power is increased with blood pressure control and LDL/HDL < 2 can be a adequate target.