Background: Diastolic heart failure (DHF) is common and significant cardiovascular cause of morbidity and mortality. Recently favorable effect of statins (HMG-CoA reductase) on heart failure patients was reported. We evaluated the effect of statin on the cardiac remodeling and function in model of DHF with LVH in hypertensive rats. Methods: Dahl salt-sensitive rats were fed with high salt diet until 13 weeks of age. After LVH and diastolic dysfunction was confirmed by echocardiography, rats were randomly assigned to control and statin groups. Statin group were treated with rosuvastatin until 20 weeks of ages. Serial echocardiography and hemodynamic monitoring by miniaturized conductance catheter were performed. Results : Echocardiographic parameters did not show significant difference between groups. In hemodynamic monitoring, systolic functional parameters were similar between groups, whereas end diastolic pressure-volume relationships were lower in statin group, suggesting improvement of myocardial stiffness in this group (p<0.05). Pathological analysis showed attenuation of interstitial and peri-vascular fibrosis in statin group. Conclusion: Statin therapy on DHF which started after LVH development and diastolic dysfunction did not alleviate LVH, but attenuated the myocardial fibrosis and the progression of myocardial stiffness.