Multi-Detector Computed Tomography (MDCT) has been considered as a noninvasive alternative method for evaluating stent restenosis. However, it has been reported that the diagnostic accuracy of MDCT for stent stenosis had severe limitations because of high-attenuation stent-related artifacts. 64-MDCT exhibits better spatial and temporal resolution than 16-MDCT. We assessed the diagnostic accuracy of 64-MDCT by comparing with conventional coronary angiography in subjects who had previous stent implant in the coronary artery. We examined 51 patients (age 60.76짹12 years, 39 (76.4%) men) with 72 implanted coronary stents. The mean stent size was 2.96짹0.37 mm. Types of stent comprised Cypher짰 (52, 72%), Taxus짰 (16, 22%), Endeavor짰(1, 1.3%) and bare metal stent (3, 4.1%). 69 stents (94%) were possible to be evaluated by 64 MDCT. Quantitative conventional coronary angiography found stent restenosis in 13 stents (18%). The diagnostic accuracies of 64-MDCT for stent restenosis are shown in Table1. The diagnostic accuracy of 64-MDCT for assessing stent restenosis showed moderate sensitivity and positive predictive value, high specificity and negative predictive value. 64-MDCT also exhibits potential as a useful noninvasive imaging method for stent restenosis evaluation as well as de novo lesion detection.