Background: Although drug eluting stent (DES) improved angiographic and clinical outcomes in many subsets of coronary artery disease, left main (LM) disease is still challenging field in interventional cardiology. This study analysed single center (Seoul National University Bundang Hospital, SNUBH) registry of left main intervention retrospectively. Methods: The patients receiving LM intervention with DES were searched in SNUBH data base. Pre, post PCI, 6 month follow up quantitative coronary angiography data, inhospital and 6-month clinical outcome were analysed. Contiguous or long stenting involving left main (> 33mm in stent length) were excluded. Results: From September, 2003 to December, 2006, 71 patients were treated with DES for their LM disease. A total of 70% were male and mean age was 65.3짹11.9 years. Acute coronary syndrome was predominant diagnosis(49%). Intra-aortic balloon pump and glycoprotein IIb/IIa were used in 14.1% and 15.5% respectively. Lesions were located in LM ostium (21.1%), shaft (9.9%), distal LM involving left anterior descending artery(LAD) or left circumflex artery(LCX) ostium (69%). Stenting technique was various according to lesion characteristics: 66.2 % LM stenting alone or cross-over stenting, 21.1% kissing stenting, 9.9% Crushing stenting, 2.8% T or V stenting. In cases of cross-over stenting, final kissing balloon was done only in 21.6%. 6-month binary instent restenosis rate was 16.8%. 6-month late loss was 0.19짹0.66mm in LM to proximal LAD, 0.18짹0.72mm in LM to proximal LCX. 2 inhospital deaths (2.8%) occurred. One was by acute stent thrombosis, the other was by pump failure (sudden cardiac death survivor). 6-month major adverse cardiac events (MACE) rate was 14.1%, including cardiac death (2.8%), myocardial infarction (2.8%), target vessel revascularization (11.3%). Emergency procedure was an independent predictor of 6-month MACE (OR, 19.6; 95% CI 2.96-130.67). Conclusion: LM stenting has still unfavorable results even in DES era. Because adverse outcomes occurs by other causes as well as instent restenosis, such as stent thrombosis, de novo lesion progression, Coronary artery bypass graft(CABG) should be considered as the first choice of treatment.