Background: We studied the relationship among soluble receptor for advanced glycation end products (sRAGE), AGE and inflammatory markers according to RAGE Gly82Ser gene polymorphism, obesity and a low-grade inflammatory state. Methods and Results: we measured circulating concentrations of sRAGE, AGE and inflammatory markers (CRP and IL-6) in Korean men. A total of 1252 men aged 30~70 years with body mass index���18.5kg/m2 were recruited. Anthropometric parameters, lipid profiles, glucose, RAGE G82S polymorphism, sRAGE, AGEs, and inflammatory markers (CRP and IL-6) were measured. sRAGE concentrations were lowest in those with homozygous mutation,���S/S���(G/G: 1036.3짹40.3, G/S: 807.0짹49.6 and S/S: 443.0짹47.8pg/ml, p<0.001), which maintained after adjusted for age, BMI, cigarette smoking and alcohol drinking (p<0.001). Stepwise regression showed that RAGE Gly82Ser genotype (棺-coefficient=-0.384, p<0.001) and BMI (棺-coefficient=-0.168, p=0.001) were major influencing factors on sRAGE concentration. Obese subjects (BMI���25kg/m2) had significantly lower levels of sRAGE(831.7짹36.7pg/ml) than non-obese subjects (1022.7짹47.8pg/ml) (p=0.009). In Obese subjects, the ���S/S���group had lower concentrations of sRAGE (439.5짹57.7pg/ml) than the G/G (917.5짹45.7 pg/ml) or the G/S group (768.8짹56.1pg/ml) (p<0.001). Furthermore, the obese subject with the S/S genotype showed higher concentrations of AGE and CRP comparing with those with the G/G or G/S genotype (p=0.012 and p=0.006, respectively). Conclusion: sRAGE is influenced by RAGE G82S polymorphism and obesity status as a result of enhanced AGE-RAGE binding affinity. Inflammatory condition such as obesity not only decreases sRAGE levels but also increases AGE and CRP levels particularly in subjects with RAGE 82 S/S genotype.