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The MV VTI(mitral valve velocity-time integral) and A’ velocity are useful variables that can predict the exercise duration in hypertensive patients with isolated diastolic dysfunction.
¹ 국민건강보험공단 일산병원 심장내과 ² 연세 의료원 심장내과
¹ 윤세정, ² 박성하² 김성애² 최의영² 하종원² 정남식
Abstact The main complaint of hypertensive patients with isolated diastolic dysfunction is dyspnea or dyspnea on exertion. But the transthoracic echocardiography(TTE) in resting state cannot detect the exercise capacity. So we tried to assess the capacity of exercise by multiple variables in resting TTE. Methods Total 50 hypertensive patients with dyspnea on exertion and isolated diastolic dysfunction(46% of male, mean age of 59.2 ± 8.9) were enrolled and underwent exercise echocardiography. A graded supine bicycle exercise and two-dimensional and Doppler echocardiographic study were performed at the same time. Basic echocardiographic variables were measured during resting and exercise. The exercise echocardiography was stopped when severe dyspnea and fatigue was occurring. Results The baseline systolic function and RVP were normal with borderline enlarged LA size(29.25 ± 6.62 cm3/m2) and slightly elevated E/E’. LV filling pattern revealed 86% of relaxation abnormality(14% of normal filling). The exercise duration was correlated with age, E, E’ and MV VTI(r = -0.508, p <0.0001 ; r = 0.346, p = 0.014 ; r = 0.316, p = 0.025 ; r = 0.340, p = 0.016). The age, A’ velocity and MV VTI were significant predictor of exercise duration(β =-0.48, p =0.02 ; β =0.36, p =0.04 ; β =0.38, p =0.03) Conclusion In patients with isolated diastolic dysfunction, the MV VTI and A’ velocity-the mitral annular tissue velocity in atrial kick are significant predictors of exercise capacity. MV VTI is influenced by diastolic LV compliance and contractile function of LA(atrial kick). We can assess the patients with isolated diastolic dysfunction in view of the MV VTI and A’ velocity.


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