Abstact
The main complaint of hypertensive patients with isolated diastolic dysfunction is dyspnea or dyspnea on exertion. But the transthoracic echocardiography(TTE) in resting state cannot detect the exercise capacity.
So we tried to assess the capacity of exercise by multiple variables in resting TTE.
Methods
Total 50 hypertensive patients with dyspnea on exertion and isolated diastolic dysfunction(46% of male, mean age of 59.2 ± 8.9) were enrolled and underwent exercise echocardiography. A graded supine bicycle exercise and two-dimensional and Doppler echocardiographic study were performed at the same time. Basic echocardiographic variables were measured during resting and exercise. The exercise echocardiography was stopped when severe dyspnea and fatigue was occurring.
Results
The baseline systolic function and RVP were normal with borderline enlarged LA size(29.25 ± 6.62 cm3/m2) and slightly elevated E/E’. LV filling pattern revealed 86% of relaxation abnormality(14% of normal filling). The exercise duration was correlated with age, E, E’ and MV VTI(r = -0.508, p <0.0001 ; r = 0.346, p = 0.014 ; r = 0.316, p = 0.025 ; r = 0.340, p = 0.016). The age, A’ velocity and MV VTI were significant predictor of exercise duration(β =-0.48, p =0.02 ; β =0.36, p =0.04 ; β =0.38, p =0.03)
Conclusion
In patients with isolated diastolic dysfunction, the MV VTI and A’ velocity-the mitral annular tissue velocity in atrial kick are significant predictors of exercise capacity. MV VTI is influenced by diastolic LV compliance and contractile function of LA(atrial kick). We can assess the patients with isolated diastolic dysfunction in view of the MV VTI and A’ velocity.
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