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ȣ - 510469 206 |
| Multiple antiplatelet therapy after drug-eluting stent implantation: How long and How many? |
| 가톨릭대학교의과대학 |
| 박찬석, 전두수,김동빈,박철수,김범준,진승원,장기육,김희열,유기동,정욱성,김재형,최규보 |
Background: The patients underwent DES implantation should take antiplatelet medications. There is no definite recommendation for adequate combination and duration of the antiplatelet medications. Methods and results: Since May 2005, we recruited the patients at 8 hospitals of Catholic university medical college. The patients were divided into two groups. (Protocol-1, SES or ZES in simple lesion; Protocol-2, SES or ZES in complex lesion and PES in all coronary lesion) The primary end point was all-cause death, MI and stent thrombosis (ST). Total 1035 patients were enrolled until July 2007. Mean duration of follow up was 10.0±6.8 months. Conclusion: There were no differences of clinical outcomes between the groups. It should be notified that there was only one cardiac death in protocol 1-3. We are planning to recruit more patients for further analysis.
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1-1
|
Aspirin
/clopidogrel continuously |
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1-2
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Aspirin
/Clopidogrel for 3 months |
Then,
Aspirin/ cilostazol continuously |
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1-3
|
Aspirin
/Clopidogrel for 3 months |
Then,
only Aspirin continuously |
|
2-1 |
Aspirin
/Clopidogrel /cilostazol for 6 months |
Then,
Aspirin/ clopidogrel continuously |
|
2-2
|
Aspirin/
clopidogrel continuously |
|
2-3
|
Aspirin/
Clopidogrel/ cilostazol for 6 months |
Then,
Aspirin/ cilostazol continuously |
|
2-4 |
Aspirin/Clopidogrel
for 6 months |
Then, Aspirin/ cilostazol |
|
|
Primary
end point |
|
1-1
(n=108) |
Definite
ST (n=1) Possible (n=1) |
|
1-2
(n=88) |
Possible
ST (n=1) |
|
1-3
(n=85) |
Cardiac
death (n=1) |
|
2-1
(n=190) |
Definite
ST
(n=2), Possible
ST (n=1), Non cardiac death (n=1) |
|
2-2
(n=210) |
Definite
ST
(n=1), Cardiac death (n=1) |
|
2-3
(n=162) |
Definite
ST
(n=1), Cardiac death (n=1), Non cardiac death (n=1) |
|
2-4
(n=193) |
Definite
ST
(n=1), Non cardiac death (n=1) |
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