Objective Central arterial stiffening and early atherosclerosis are common features of hypertensive patients. We sought to determine the different associations between the indices of regional arterial stiffness and carotid intima-media thickness(CIMT) in hypertensive patients. Methods We performed concurrent pulse-wave velocity(PWV) and carotid ultrasound examinations on 285 (156 males, age: 55짹10) treated hypertensive patients. Heart to femoral PWV(hfPWV) and brachial to ankle PWV(baPWV) were used as indices of central and peripheral arterial stiffness. The mean and maximum CIMTs were measured at the common carotid arteries. Results The mean and maximum CIMTs were well correlated with log hfPWV(r=0.287, p<0.001, r=0.268, p<0.001) and log baPWV(r=0.193, p=0.001, r=0.189, p=0.001). Multiple linear regression analysis, controlled for variables such as age, body mass index, fasting glucose and lipid profiles, revealed that mean and maximum CIMTs were independently associated with hfPWV, which is an index of central arterial stiffness(棺=0.192, p=0.004, 棺=0.185, p=0.006). However, the mean and maximum CIMTs were not independently associated with baPWV(棺=0.070, p=0.258, 棺=0.081, p=0.198). These associations were consistent even after controlling for antihypertensive medications. Conclusion The CIMT was associated with central arterial stiffness, but not peripheral arterial stiffness, independent of age, body mass index, fasting glucose, lipid profiles, and antihypertensive medications in treated hypertensive patients.