Background: High sensitivity CRP (hsCRP) and fibrinogen have been known as inflammatory and rheological parameter and coagulation parameters. Although the combination of hsCRP and fibrinogen may have an additive effect to identify the cardiovascular events after acute myocardial infaction (AMI), this association has not been clearly investigated in patients with AMI. Methods: Four-hundred one consecutive patients with AMI (289 men, mean age 62 짹 12 years) were enrolled in Infarction Prognosis Study (IPS) registry. At the time of enrollment, the patients underwent an initial laboratory assessment including hsCRP and fibrinogen. Subjects were classified as hsCRP level (10 mg/L) and fibrinogen (400 mg/dl). Mean follow-up duration of the patients were 12 month (range, 1 to 24 month) Results: The MACE was occurred in 38 patients. Both hsCRP (���10 mg/L) and fibrinogen level (��� 400 mg/dl) were independently associated with MACE and two biomarkers were significantly correlated with each other (r = 0.525, p < 0.001). The event-free survival curve showed that patients with ���10 mg/L in hsCRP and ��� 400 mg/dl in fibrinogen were significantly higher probability of incidence of MACE than other patients (OR = 4.996, 95% CI: 2.122-11.763). Conclusion: Combination of hsCRP and fibrinogen has an additional value in predicting cardiovascular events. Therefore, combination of two biomarkers may be a useful marker of cardiovascular events in patients with AMI