Background : Adiponectin is an adipose tissue-derived bioactive mediator that is believed to have significant antiatherogenic properties in humans. However, there are still limited data on association between serum adiponectin level and coronary artery disease(CAD). The aim of this study was to know the association between serum adiponectin levels and clinical and angiographic profiles of CAD. Method and Results : Blood samples for measurement of serum adipocytokines concentrations were collected from patients with moderate to severe CAD( Gensini score higher than 15, n=53) and control subjects with normal coronary arteries (n=57). In CAD group, serum adiponectn levels measured by enzyme linked immunosorbent assay were significantly lower than those of control group (3.9 짹 2.7 vs 4.9 짹 3.1 , p = <0.05 ). There were no significant differences of serum leptin concentrations between the two groups. Conclusion : Low serum adiponectin concentrations are likely to be associated with coronary artery disease. in association with other metabolic and inflammatory markers. Thus, measurement of serum adiponectin concentration may serve as one of screening tests facilitating early intervention of coronary artery disease.