Background: Early statin treatment has beneficial effects on prognosis after acute coronary syndrome as a secondary prevention. Stains were also commonly used in the patients who have hypertension or diabetes. However, no data have been reported with regard to the prognosis in the patients who chronic pre-treatment before the development of myocardial infarction. Methods: The primary PCI was performed in 3277 patients who were registered in Korea Acute Myocardial Infarction Registry (KAMIR) from Nov 2005 to Dec 2006. In this registry, we investigated the 1459 patients with hypertension history from the 3277 patients (men: 957, age 65.7짹11.9 years). The study group were divided were divided into two groups: the patients in chronic pretreatment of statin (group I: n=106) and did not medicate the statin (group II: n=1353). The clinical, angiographic characteristics and in-hospital death were compared between the two groups. Result: In baseline clinical characteristics, there were no significant differences between two groups, in age, gender, risk factors (smoking, familial history, BMI). But there were significant difference in hyperlipidemia history, Killip class (group I: 1.65짹0.978, group II: 1.44짹0.855; p=0.03) and TIMI risk scores (group I: 3.42짹1.17, group II: 2.89짹1.03; p<0.01), and these findings mean that group I was composed of high risk patients than Group II. Baseline laboratory findings were different between the two groups in cholesterol profiles (cholesterol level was lower in group I). However, there were no significant difference between groups in cardiac enzymes, hsCRP, NT-pro BNP level, and angiographic findings. The in-hospital death was developed in 4 patients of group I (4.7%) and 93 patients of group II (6.87%). The results show the tendency that the incidence of in-hospital death was lower in the patients of chronic pretreatment. Conclusion: Although a non-randomized observational study, the present study suggested that statin pre-treatment may improve the clinical outcomes and reduce the in hospital death in the patients of acute myocardial infarction who undergoing primary PCI.