Background: Chronic renal insufficiency (CRI) has known to be related to higher rates of repeat pecutaneous coronary intervention (PCI) and mortality. We investigated whether CRI has adverse impact on clinical and angiographic outcomes in a series of Asian population in the drug eluting stent (DES) era. Method: A total 71 CRI patients (pts) whose creatinine level on admission was higher than 2mg/dL and underwent PCI with DES were classified as CRI group. A total 782 pts with normal renal function were classified as Non-CRI group. Angiographic and clinical outcomes at 6 months were evaluated. Result: Baseline characteristics were similar except CRI group had higher mean BUN levels (21.66짹10.66 vs. 16.36짹15.48, p=0.001) and creatinine levels (1.85짹1.60 vs.1.03짹1.02 mg/dL, p=0.001) than those of Non-CRI group. At 6 months, the CRI group had significantly higher incidence of binary restenosis, higher restenosis percent and late loss (Table). Although the incidence of Q-wave MI, repeat PCI, MACE and stent thrombosis were not different between the two groups, mortality was higher in the CRI group. Conclusion: Even in the era of DES, chronic renal insufficiency had an adverse impact on the clinical and CAG outcomes of PCI with higher rates of intrastent restenosis and cardiac death.