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ȣ - 510633 281 |
| Comparable Outcomes of Sirolimus- and Paclitaxel-Eluting Stents in Diabetic Patients Undergoing Percutaneous Coronary Intervention |
| 고려대학교 구로병원 순환기내과 |
| Kang-yin Chen, 나승운, Zhe Jin, Yoshiyasu Minami,김지훈, 나진오,서순용, 최철웅, 김진원,김응주,박창규,서홍석,오동주 |
Background:DES has drastically changed landscape for PCI in diabetic pts,with reductions in angiographic restenosis rates and need for repeat revascularization procedures.Whether different types of DES have similar efficacy in Asian population with diabetes is still controversial.Method:A total of 270 diabetic pts who underwent PCI with Sirolimus(SES group;n=135 pts,178lesions) or Paclitaxel(PES group;n=135pts,246 lesions)-eluting stents were enrolled.Angiographic and clinical outcomes at 6 months were evaluated.Result:Both group had similar baseline clinical and procedural characteristics.At 6 months,SES group showed less late loss and restenosis percent;however incidence of binary restenosis was not different between two groups.Despite difference in angiographic outcomes,clinical outcomes(death, Q-wave MI,TLR,TVR and MACE) were similar between two groups(Table).There was no incidence of acute, subacute and late stent thrombosis.Conclusion:Although SES has reduced late loss and restenosis percent compared with PES,these angiographic benefits was not translated into better clinical outcomes in diabetic pts.Long term follow up of this study population will be needed for final conclusion.
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Table:
Angiographic and clinical outcomes at 6 months
|
Variable, n (%) |
SES Group
(n=135 pts, 178
lesions) |
PES Group
(n=135 pts, 246
lesions) |
P
value |
|
Stent
diameter,
mm |
3.05±1.57 |
2.95±0.79 |
0.359 |
|
Stent length,
mm |
25.87±6.82 |
24.54±6.40 |
0.071 |
|
Binary restenosis |
8
(4.5) |
17
(6.9) |
0.297 |
|
Restenosis percent,
% |
22.55±22.34 |
30.93±22.84 |
0.007 |
|
Late loss,
mm |
0.47±0.53 |
0.90±0.71 |
0.001 |
|
Cardiac death |
5
(3.7) |
5
(3.7) |
1.000 |
|
Total death |
9
(6.7) |
6
(4.4) |
0.425 |
|
Q-wave MI |
0
(0) |
0
(0) |
-- |
|
TLR |
1
(0.7) |
1
(0.7) |
1.000 |
|
TVR |
1
(0.7) |
1
(0.7) |
1.000 |
|
TVR-MACE |
10
(7.4) |
7
(5.2) |
0.452 |
|
Stent thrombosis |
0
(0) |
0
(0) |
-- |
|
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