Background:DES is being used as one of the best treatment choice fort reatment of diffuse coronary lesions but outcomes are still controversial.We investigated efficacy and safety of DES in treatment of diffuse lesions (>30mm).Methods:From Sept 2004 to Dec 2006,853 pts underwent PCI with DES and 268 pts with diffuse lesions were treated with either Sirolimus-(SES group, n=125pts) or Paclitaxel-(PES group,n=143pts)-eluting stents.Mid-term angiographic and clinical outcomes of two groups were compared.Results:Baseline clinical and procedural characteristics were similar between two groups except lesion length was longer(42.1짹17.0vs49.3짹22.9 p=0.002) and there was trend toward more CTO(5.4% vs11.5%,p=0.07) in PES group.At 6 months,angiographic outcomes including rate of binary restenosis, minimal lumen diameter(MLD), % diameter stenosis(DS) and late loss were worse in PES group.However,there were no differences in clinical outcomes(Table).Multivariate analysis showed that stent type is independent predictor of restenosis(OR 0.21,95% CI0.06-0.76, p=0.017).The lesion length, stented length and rate of CTO were not independent predictors of restenosis.Conclusions:DES is safe and effective in treatment of diffuse coronary lesion.Although PES showed higher rate of restenosis compared to SES,this result was not translated into worse clinical outcomes.