Background: Drug-eluting stents (DES) have dramatically reduced the need for revascularization or restenosis rate in clinical trials. However, their benefits are not established in large coronary artery disease. The aim of this study is to evaluate the efficacy and safety of percutaneous coronary intervention (PCI) with DES in large coronary artery disease according to the types of implanted stents. Method: 527 patietns (bare metal stent: BMS 150 patients/155 lesions, sirolimus-eluting stent: SES 279/300, paclitaxel-eluting stent: PES 98/100), who had large coronary artery (3.5mm ��� reference vessel diameter ��� 4.0mm) disease, were consecutively enrolled in three interventional cardiology centers since April 2003 to July 2005. All patients were divided into three groups according to the types of stents (group 1: BMS, group 2: SES, group 3: PES). Two-year clinical outcomes were analyzed. Results: Major adverse cardiac events for 2 year were 16.2 % in group 1, 5.7 % in group 2, 3.9 % in group 3 (p<0.001). Other data are in the following figure. Two-year clinical follow-up was available in 91.6%, angiographic follow up in 51.8% Conclusion: Long-term clinical outcomes after PCI in large coronary artery disease were better with DES. Therefore, the selection of stent in the era of DES might be revisited