Objectives : Many of the patients showing no evidence of atherosclerotic narrowing in coronary angiogram complain chest pain and the management of these patients is troublesome for many cardiologists. The aim of this study was to analyze the parameters related to baseline coronary flow velocity(CFV) and coronary flow reserve (CFR) using transthoracic Doppler echocardiography(TTE) in these subjects., Methods : 354 subjects (mean age: 55짹11 years, M:F ratio = 186:168) with angina or angina-like chest pain and a normal coronary arteriogram were enrolled. CFR using TTE and adenosine or dipyridamole was measured within two weeks after coronary angiogram. We analyzed the clinical, electrocardiograpic, echocardiographic and laboratory parameters in these subjects. Results : 1. There was an inverted correlation between baseline CFV and CFR (r=-.374, p<.001). 2. The baseline CFV was closely related to LV mass index(LVMI, r=.149, p=.011), fasting blood sugar level(FBS; r=.237, p<.001) and LVH criteria on ECG (18.4짹9 vs 21.7짹10, p=.002), respectively. 3. The baseline CFV on highest 75% quartile (23.2 cm/s) was closely related to LVH criteria on ECG (odds ratio: 2.960 [95% confidence interval: 1.642–5.334], p<0.001) in multivariate analysis. 4. CFR was closely related to age(r=-.173, p=.003), LVMI(r=.-186, p=.005), HDL(r=.169, p=.005), and LVH criteria on ECG (2.79짹.87 vs 2.44짹.83, p=.002), respectively. 5. In multivariate analysis the independent factors related to CFR <2.0 were LVH criteria on ECG (odds ratio: 2.200 [95% confidence interval: 1.041–4.648], p = 0.039) and HDL level (odd ratio: 1.037 [95% confidence interval: 1.004–1.072], p = 0.028). Conclusions : Our results show there are many factors relating CFV and CFR. Among these factors the baseline CFV is the important factor determining CFR and CFR <2.0 suggesting ischemic range is closely related to LVH and HDL level in subjects with chest pain and normal coronary angiogram.