Background The recently introduced method, speckle tracking echocardiography, represents simplified, objective, and angle-independent modality for quantification of regional myocardial deformation. As published, there was no significant change in LV torsion with age, there might be some difference in LV rotation at base and apex. The purpose of this study was to assess the relationship of LV rotation with age in children. Methods Twenty healthy children were recruited and divided into two groups of ten preschool age (2 ~ 6 years of age) and ten school age children (7 ~ 12 years of age). After obtaining conventional echocardiographic data, apical and basal short axis rotations were assessed with speckle tracking echocardiography. LV rotations in basal and apical short axis planes were determined of six myocardial segments along the central axis. Results There was no significant change in apical and basal LV rotation with age between preschool and school age children. However, there was a certain trend between two age groups in each basal and apical rotation data. In basal rotation, the values of preschool age children are greater than those of school age children at anteroseptal, anterior, lateral, posterior, inferior, and septal, all six segments. Conclusion There was some trend of incremental rotation value in preschool age children rather than school age children. Although there was no statistically significant age-related change in LV rotation between these two groups, the further investigation should be continued.