Background- Albuminuria is a surrogate marker of endothelial dysfunction and a predictor of cardiovascular events. Recent evidences suggested that pre hypertension is associated with endothelial dysfunction and albuminuria. However, data are limited with regard to the relationship between albuminuria and blood pressure in non-hypertensive range in non-diabetic and non-hypertensive individuals. Therefore, we sought to evaluate the association between`blood pressure in non-hypertensive range and albuminuria measured by urine albumin creatinine ratio (UACR) in a Korean general population.
Methods - The subjects were selected from the Korean Genomic Rural Cohort conducted on a representative adult population (age > 40 years) .We excluded subjects with overt proteinuria or with treatment of diabetes mellitus, hypertension, dyslipidemia and enrolled 2,048 non-diabetic and non-hypertensive general population (787 male, 1,261 female) with normal renal function. The subjects were stratified into two groups by their UACR values (Normoalbuminuria< 30μg/mg and 30 μg/mg < microalbuminuria <300 μg/mg). We investigated associations among blood pressure in non-hypertensive range, other cardiovascular risk factors and UACR values.
Results-The prevalence of microalbuminuria was 8.1%. In subjects with microalbuminuria, there were significantly higher systolic blood pressure (sBP, p=0.002), diastolic blood pressure (dBP, p=0.003), waist circumference (p=0.02), total cholesterol (p=0.005), LDL-cholesterol (p=0.046), triglyceride(p<0.001), fasting plasma glucose (p=0.04), lower HDL-cholesterol (p=0.002) and higher prevalence of metabolic syndrome. However, there was no difference in age, sex, and smoking status in two groups. The hierarchical multiple regression analysis showed the systolic blood pressure and diastolic blood pressure was significantly associated with UACR values (p =0.001).
Conclusion- The systolic and diastolic blood pressure in non-hypertensive range is an independent risk factor for albuminuria in a Korean non-diabetic and non-hypertensive general population.
|
