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Relation of Aortic upper wall tissue Doppler image velocity to aortic stiffness and diastolic function
고려대학교 구로병원 심혈관센터
서순용, 김응주, Kang-yin Chen, Zhe Jin, Yoshiyasu Minami, 김지훈, 신승용,주형준, 나진오, 최철웅, 김진원, 나승운, 박창규, 서홍석, 오동주
Background: Aortic stiffening contributes to the LV afterload, hypertrophy and substrate for diastolic dysfunction. It is also known that aortic elastic properties could be investigated with colour tissue dopper imaging (TDI) in aortic upper wall. Therefore we would like to seek to relation of aortic wall TDI and aortic stiffness and other parameters of diastolic dysfunction. Method: We examined aortic upper wall of 500 patients by TDI at the 3cm above the aortic valve. We measured aortic diameter at systolic, diastolic phase and the velocity of TDI in the aortic wall, mitral annulus (Em, Am, Sm) and PW of E, A, DT in the mitral inflow. We excluded the patient with arterial hypertension or reduced LV ejection fraction or significant valvular heart disease. So a total of 126 (mean age 53.8±13.9, male 49.2%) patient were enrolled in this study and divided normal LV filling group (N=31) and abnormal LV filling group (N=95) depending on E, A, DT, Em, Am, Sm. Blood pressure were measured in the brachial artery before the echocardiogram. Result: Aortic wall early and late systolic velocity and late diastolic velocity were not different between two groups. Only Aortic wall early diastolic velocity was significantly reduced in abnormal LV filling group and related to aortic stiffness index (r=-0.25, P=0.008), distensibility (r=0.27, P=0.003), Em (mitral annular velocity in early diastole r=0.448, P=0.001), E/Em (r=-0.25, P=0.005) Conclusion: Aortic wall early diastolic velocity is decreased significantly in abnormal LV filling patient. And it is significantly related to aortic stiffness, distensibility and abnormal LV filling, Em, E/Em. TDI of the aortic wall can be a new tool for aortic stiffness, distension and diastolic function.

Table. Aortic colour doppler imaging parameters and diastolic parameters 

 

Normal LV filling (N=31)

Abnormal LV filling (N= 95)

P

Aortic wall early diastolic velocity (cm/sec)

8.18 ± 2.87

6.19 ± 2.50

0.001

Aortic distensibility

3.20 ± 2.88

2.22 ± 1.80

0.035

Aortic stiffness index

3.01 ± 0.72

3.39 ± 0.84

0.028

E/Em

7.7± 2.47

11.3 ± 3.86

0.001



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