Purpose: The lack of nocturnal fall in blood pressure (BP) determines a more serious target organ damage in patients with essential hypertension (EH). Also, morning blood pressure surge (MBPS) seems to be a risk factor for cardiovascular events. Arterial stiffness is associated with organ damage in patients with primary hypertension. The aim of this study was to evaluate relationship of pulse wave velocity (PWV) and MBPS in dippers and non-dippers with EH. Methods: We enrolled 40 patients ( 50.4 yrs) who was recently diagnosed as EH. After 24 hr ambulatory blood pressure monitoring, they were divided into 25 non-dipper and 15 dipper group according to nocturnal BP fall. Dipper was defined as a 10-20% fall in nocturnal BP. MBPS was defined as the difference between the average of systolic BPs during the 2h after awakening and 1h that included the lowest sleep BP. We compared MBPS, femoral-ankle (fa)and carotid-radial (cr) PWV, LV mass index and LA volume index in two groups. Results: There was not different in 24hr average systolic and diastolic BP, ejection fraction, LV mass index and LA volume between both groups. The femoral-ankle PWV of non-dipper group was significantly higher than it of dipper (11.44±1.55 vs 10.08±1.55 cm/sec2, respectively). MBPS in non-dipper group was positively correlated to crPWV (p=0.007) and LA volume (p=0.026) but in dipper was not. Conclusions: Impaired circadian pattern of blood pressure might be associated with the decrease of the arterial elasticity and target organ damage in patients with EH.
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