Background and Objectives竊� The purpose of this study was to evaluate the long term vascular impact of Intracoronary infusion of mobilized peripheral blood stem cells (PBSCs) by Granulocyte Colony-Stimulating factor (G-CSF). Subjects and Methods竊� The study included 188 patients (control: 82, cell infusion: 79), who enrolled in MAGIC Cell trials. 165 patients and 8 patients underwent revascularization with drug eluting stent (DES) and with bare metal stent (BMS) respectively and 10 patients did revascularization with both DES and BMS. Cell infusion group underwent Intracoronary infusion of mobilized PBSCs by G-CSF. Mean follow-up duration is 12.77  8.62 months (range: 1 – 122.5). We evaluated the rate of additional percutaneous coronary intervention (PCI), target vessel, unexpected readmission due to acute coronary syndrome or heart failure and death. Results竊� Sixteen patients in the control group and 10 patients in the cell infusion group underwent revascularization during follow-up (p-value 0.131). Revascularizations were performed due to de novo lesion progression (control vs. cell infusion: 12 vs. 5, p-value 0.049) and target lesion revascularization (TLR)/target vessel revascularization (TVR) (control vs. cell infusion: 6 vs. 6, p-value 0.896). Most revascularization was performed at scheduled follow-up angiography (control vs. cell infusion: 15 vs. 8), only 3 patients (control vs. cell infusion: 2 vs. 1) underwent revascularization due to myocardial infarction or worsening of angina. During follow-up, 3 death (1 non-cardiac, 2 cardiac) in the control group and 3 death (2 non-cardiac, 1 cardiac) in the cell infusion group was reported. Conclusion竊� Intracoronary infusion of mobilized PBSCs by G-CSF had tendency to decrease the rate of additional revascularization compared with control group. Especially, this procedure had protective effect on de novo lesion progression.