Background and Objective: The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. The purpose of this study was to evaluate the prevalence of MetS and an independent association of MetS with myocardial infarction between the Korean genomic rural cohort (KGRC) and Korean acute myocardial infarction registry (KAMIR).
Methods: The study subjects were selected from the KGRC, an ongoing epidemiologic study conducted on a representative senior population and KAMIR, a registry study in patients with Korean acute myocardial infarction. We enrolled 12,859 subjects [7,971 in KGRC (mean age; 56.5 ± 8.1) and 4,896 in KAMIR (mean age; 58.0 ± 8.2)]. The MetS was defined according to the modified ATP III and IDF criteria.
Results: According to ATP III and IDF criteria, the prevalence of MetS was higher in KAMIR than KGRC population (50.2% vs. 35.4% in ATP III criteria, 28.7% vs. 22.7% in IDF criteria, p < 0.001 in both criteria). The prevalence of abdominal obesity was higher in KAMIR patients (33.7% vs. 31.6%, p=0.016) and that of high glucose defined by ATP III and IDF was higher in KAMIR patients (80.7% vs. 16.8% by ATPIII, p <0.001, 88.3% vs. 27.8% by IDF, p < 0.001). After adjustments for age, sex, smoking, LDL-cholesterol and family history of ischemic heart disease, the odds ratio of MetS for myocardial infarction was 2.62 (95% confidence interval 2.38 to 2.88).
Conclusions: The prevalence of MetS was significantly higher in myocardial infarction patients in KAMIR than general population in KGRC. MetS might be an independent
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