To evaluate the clinical value of dual source computed tomography (DSCT) for preoperative evaluation of coronary artery stenosis and severity of aortic valve regurgitation (AR).
A total of 18 consecutive surgical candidates (14 men, 4 women: mean age, 59 years ± 12.80) for aortic valve regurgitation were studied by DSCT (Somatom Definition, Siemens) without heart rate control. All patients signed an informed consent form. The diagnostic accuracy of DSCT coronary angiography in the detection of significant coronary artery stenosis (>50%) were evaluated in comparison with conventional coronary angiography, which was performed in all patients. In addition, the correlation between central valvular leakage area (aortic regurgitation area [ARA]) during diastole planimetrically measured with DSCT (ARACT) and the grade of AR severity as measured by transthoracic echocardiography (TTE) were evaluated by Spearman’s rank coefficient.
The average heart rate during CT scanning was 69 beats per minute (bpm) ± 18.99 (range, 49-133 bpm) and 9 patients had a heart rate of above more than 65 bpm. Overall, 226 (98%) of 231 coronary artery segments were classified as assessable. In segment-by-segement comparison with catheter angiography, DSCT yielded a sensitivity of 72.7% and specificity 100%, positive predictive value of 100%, and negative predictive value of 98.6% in detecting significant coronary artery stenosis. In diastolic phase reconstruction, central leakage area of aortic valve could be correctly detected by DSCT in all patients. The planimetric measurement of ARACT showed significant correlation with the grade of AR as measured by TTE (r = 0.837, p = 0.001).
With improve temporal resolution, DSCT coronary angiography provides high diagnostic accuracy for detection of coronary artery stenosis and evaluation of severity of aortic regurgitation.
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