Background: Although serial changes in necrotic core and calcium are regarded as surrogates for the bioresorption process in patients treated with the bioresorbable everolimus-eluting vascular scaffolds (BVS), these temporal changes have not yet been fully investigated. Shin���s method may be offer a more suitable technique for this analysis because it includes all the contents of both the lumen and vessel wall. Objective: The purpose of this study was to assess the serial changes of necrotic core and dense calcium content in coronary lesions that were treated with a BVS implant using Virtual Histology-intravascular ultrasound (VH-IVUS) analyzed using Shin���s method. Methods: A total of 29 patients (92 coronary segments) were imaged to evaluate the serial changes in necrotic core and dense calcium using Shin���s method. Lesions treated with a BVS implant were analyzed with serial VH-IVUS assessments, i.e., pre- and post-stenting, and at 6 months and 2 years follow-up. In Shin���s method contours are drawn around the IVUS catheter (instead of delineating the lumen) and the vessel. Results The mean necrotic core area decreased by 6.9% from post-stenting to 6 months (1.71 짹 1.03 mm짼 vs. 1.36 짹 0.91 mm짼, p = 0.027), and by 20.5% (1.71 짹 1.03 mm짼 vs. 1.20 짹 0.70 mm짼, p = 0.003) from post-steting to 2 years; while the mean dense calcium areas decreased by 27.2% (1.07 짹 0.55 mm짼 vs. 0.78 짹 0.64 mm짼, p = 0.039) from post-stenting and 2 years. Conclusions: At 2 years, absolute necrotic core and dense calcium content were significantly decreased as compared to post-stenting values. The present study demonstrates that the bioresorption process in patients who undergoing BVS device implantation can be assessed using VH-IVUS analysed using Shin���s method.