Background: Insulin resistance (IR) which can be measured with a homeostatis model assessment (HOMA) has been proposed to be traditional cardiac risk factors for coronary artery disease. But, in nondiabetic patients with stable coronary artery disease (CAD), the relationship between HOMA and severity of CAD have not been sufficiently evaluated. Method: 44 nondiabetic patients with stable CAD, which were performed coronary angiograms, were enrolled in the Eulji-HOMA registry from March 2010 to June 2010. We conducted 75 g-oral glucose tolerance tests to exclude the diabetes from the analysis in all patients. The severity of coronary artery stenosis was assessed using the Gensini score. The HOMA was used as a continuous variables, or categorical variables according to the presence of IR which was defined as a HOMA score of ��� 3.0. Results: The mean age of the subjects was 62 years, 61% were men. The CAD risk factors were common, including hypertension (52%), smoking history (40%), and familiy history of CAD (46%). Pearson���s regression analysis revealed no significant correlations between HOMA and Gensini score (r=-0.071, p=0.645). IR was found in 3 patients (6.8%). The presence of IR did not correlated with Gensini score, which was higher in patients with non-IR (20.1짹28.3 in the non-IR group vs 3.0짹0.8 in the IR group, p=0.194). Conclusion: Increased HOMA and the presence of IR were not correlated with the severity of coronary artery stenosis, which may be related to the multiple risk factors in nondiabetic patients with stable CAD.