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ȣ - 540077 254 |
| Effect of high sodium diet on arterial stiffness in subjects with sodium sensitivity |
| ¹ 동국대학교 일산병원, ² 동국대학교 경주병원 |
| ¹ 이무용, ¹ 김용석, ² 배준호, ² 나득영, ² 김소연, ¹ 김영권, ¹ 이명묵 |
Objective: High sodium diet has been known to elevate blood pressure (BP) in sodium sensitive subjects (SS). The present study evaluated the debating issue on whether high sodium diet increases arterial stiffness in SS.
Methods: One hundred and one subjects (46±17 years, 51 men) with (58±10 years, 18 men) or without hypertension (41±16 years, 33 men) were given low sodium-DASH diet (LSD, 100 mmol NaCl) for 7 days and high sodium-DASH diet (HSD, 300 mmol NaCl) for the following 7 days. On the last day of each diet, heart-femoral pulse wave velocity (hfPWV) was measured.
Results: Twenty eight subjects were classified as SS, defined as a significant change of averaged mean arterial BP (MAP) by t-test (p<0.05, 4 mmHg). The mean age of SS was higher than that of sodium resistant subjects (SR) (54±13 vs 43±17 years, p=0.001). The prevalence hypertension was higher in SS than SR (57% vs 21%, p<0.001). In SS, hfPWV after HSD was higher than that after LSD. However, this difference of hfPWV in SS was not significant after adjustment with MAP. In SR, there was no difference between hfPWV after HSD and after LSD. HfPWV of SS was higher than that of SR at baseline and after HSD, although not significant after adjustment with age, sex, smoking, heart rate, total cholesterol and MAP.
Conclusion: In SS, HSD may increase the risk of cardiovascular disease by increase of arterial stiffness, although it is BP dependent.
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hfPWV at baseline(cm/sec) |
hfPWV after LSD(cm/sec) |
hfPWV after HSD(cm/sec) |
LSD vs |
HSD |
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p(1) |
p(2) |
| All |
804 ± 153 |
792 ± 152 |
807 ± 171 |
0.211 |
0.817 |
| SS |
869 ± 125 |
827 ± 137 |
881 ± 140 |
0.004 |
0.061 |
| SR |
778 ± 156 |
779 ± 156 |
779 ± 174 |
0.901 |
0.634 |
| SS vs SR |
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| p(3) |
0.007 |
0.153 |
0.007 |
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| p(4) |
0.398 |
0.022 |
0.338 |
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Data are mean ± SD. p(1), LSD vs HSD, p adjusted with total cholesterol (TC) and heart rate (HR); p(2), LSD vs HSD, p adjusted with TC, HR, and MAP; p(3), SS vs SR, p unadjusted; p(4), SS vs SR, p adjusted with age, gender, smoking, HR, TC and MAP.
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