Purpose:
To investigate the feasibility of single scan adenosine-induced stress low dose CT myocardial perfusion imaging (MPI) using 128 slice dual-source MDCT for diagnosis of ischemic heart disease (IHD)
Material and method
Nighty five patients with chest pain and low to intermediate pretest probability were prospectively enrolled. Adenosine-induced stress coronary CT angiography (CCTA) using ECG correlated tube current modulation (mindose®) with 128 slice dual-source MDCT was performed in all 85 patients and coronary angiography (CA) with fraction flow reserve was (FFR) followed in 28 patients (29.5%, male: 18, mean age: 61.7 ± 20.5, mean heart rate: 74.6 ± 2.8 bpm) as a standard reference for evaluation of status on myocardial perfusion when significant stenoses (lumen diameter reduction > 50%) were detected on CCTA. Both CTMPI and CCTA were read by one radiologist and cardiologist with consensus
Results
Comparative diagnostic accuracy were observed in CTMPI and CCTA (the per-vessel based sensitivity, specificity, positive predictive value, negative predictive value were 93.1% vs 93.1%, 91.8% vs 85.2%, 84.3% vs 75.0%, 96.6% vs 93.3%). The effective radiation dose was 4.63 ± 2.57 mSv
Conclusion:
Single scan adenosine-induced stress low dose CTMPI using 128 slice dual-source MDCT could provide more specific information on myocardial perfusion than CCTA alone
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