OBJECTIVE: The aim of this study is to compare the 1-year mortality of cardiogenic shock (CS) caused by ST-segment elevation myocardial infarction (STEMI) between left anterior descending artery (LAD) occlusion versus non-LAD (LCX or RCA) occlusion. METHOD: We evaluated 121 eligible patients from Korea Acute Myocardial Infarction Registry (KAMIR) who completed 1-year follow up among hospital survivors from CS with STEMI. Patients were divided into two groups: Group I (LAD occlusion; n=60, 66.6짹9.7 years) and Group II (non-LAD occlusion; n=61, 65.6짹12.7 years). RESULTS: Age and sex were not differ between 2 groups. Systolic and diastolic blood pressure and heart rate were higher in group I (p<0.05). Ejection fraction was lower in group I (p<0.05). History of previous PCI, diabetes mellitus was more common in Group I (p<0.05). 1-year mortality rate was significantly higher in group I (p=0.007). On multiple logistic regression analysis, age (OR 1.16, p=0.014), beta-blocker prescription at discharge (OR 0.14 p=0.018), LAD occlusion (OR 9.45, p=0.019) were identified as 1-year mortality predictors. CONCLUSIONS: Significant difference was noted in 1-year mortality rate between patients with STEMI complicated by CS from LAD occlusion and from non-LAD occlusion undergoing primary PCI.