Background: The vascular response of human intracoronary stents represented by the extent of neointimal coverage and incidence of peri-strut low intensity (PLI) has been not documented in very old stent (> 1000 days). Methods: We evaluated optical coherence tomogrpahy (OCT) image of 107 consecutive stents (14 bare metal stents (BMS), 62 Sirolimius-eluting stents (SES), and 31 Paclitaxel-eluting stents (PES)) implanted in human coronary arteries and aged 1,000 days to 1,800 days. OCT findings including neointimal thickness (NIT) and PLI were asssessed in 29,227 stent struts at 1-mm intervals. Results: The frequency of uncovered struts or malapposition was lower in BMS (0.8%, 0.1%) than PES (9.9%, 1.6%) or SES (11.5%, 2.4%) (p<0.0001 by Kruskal-Wallis). Overall, PLI was found in 11.6% of struts. By stent level analysis, there was significant correlation between the number of PLI and mean NIT (r=0.684) and in all stent types (r=0.918, r= 0.622, r=0.616, BMS, PES, and SES, respectively) (p<0.0001). By strut level analysis, the frequency of PLI and mean neointimal thickness (NIT) were higher in BMS (20.5%, 0.38 +/- 0.28 mm) than PES (14.5%, 0.22 +/- 0.28 mm) or SES (8.3%, 0.16+/-0.19 mm) (p<0.0001 by ANOVA). Conclusion: Neointimal coverage of stent strut was still incomplete in both BMS and drug-eluting stents even after 3 to 6 years. PLI was not uncommon in all type of stents and correlated to the degree of neointimal thickness, which suggests potential relationship between neointimal proliferation and peri-strut vascular healing pathophysiology.