Background and Objectives: Recent data shows that bleeding complication after percutaneous coronary intervention (PCI) is associated with increased risk of mortality. However, little is known about the impact of bleeding in patients with diabetes mellitus who were implanted with drug eluting stent (DES). Subjects and Methods: We evaluated 862 patients with diabetes from 3148 patients who underwent PCI with DES between February 2003 and February 2006 at two centers in Korea. Cox proportional hazard models were used to determine the factors associated with mortality and bleeding. We also estimated risk of death or myocardial infarction (MI) associated with bleeding which is defined in STEPPLE major or minor criteria Results: We found that bleeding occurred in 8.8% of diabetic patients over 3 years, which was higher than non-diabetic patients with bleeding (4.2%, p=0.002). Diabetic patients with bleeding were older, had high rates of prior PCI, acute MI at presentation, lower left ventricular function, anemia, extensive coronary disease, restenotic lesion, use of intravascular ultrasound (IVUS), use of warfarin and glycoprotein IIb/IIIa inhibitor than those without bleeding. The 3-year adjusted hazard ratios (HRs) for 3-year mortality were 4.79 (95% confidence interval [CI] 1.95 to 11.77) for diabetic patients with bleeding and 3.88 (95% CI 1.76 to 8.55) for patients with MI. Other significant independent predictors for 3-year mortality included hypertension (HR 2.25), chronic kidney disease (HR 2.46) and use of IVUS (HR 2.40). Independent predictors of bleeding were chronic kidney disease (HR 3.55, 95% CI 1.96 to 6.40), acute MI at presentation (HR 2.55, 95% CI 1.46 to 4.47), use of IVUS (HR 1.28 to 3.28) and use of glycoprotein IIb/IIIa (HR 2.94, 95% CI 1.24 to 6.39) Conclusion: Bleeding after PCI with DES in diabetic patients is closely associated with increased risk of death. Several factors, including chronic kidney disease, acute MI at presentation, use of IVUS and glycoprotein IIb/IIIa inhibitor, independently predict bleeding over 3 years.