Background: There was a controversy regarding utility of screening asymptomatic CAD (coronary artery disease) in type 2 diabetic patients and which screening tests would be most useful. The purpose of this study was to explore the characteristics of the patients with CAD detected by CCTA (coronary CT angiography) in type 2 diabetes. Methods: From February 2008 to May 2010, CCTA was performed for total 608 patients with type 2 diabetes who had no symptoms of CAD. Analyses were conducted based on the results of CCTA (group A; coronary artery stenosis ��� 50%, group B; <50%). Results: Median age was 63 year-old, and 367 (60.4%) patients were male. Among 608 patients, 168 (27.6%) and 440 (72.4%) patients were included in group A and group B. One-hundred-thirteen (67.3 %) patients in group A underwent coronary angiography, and CAD was detected in 91 (positive predictive value 80.5 %), patients by coronary angiography. On multivariate analysis, the independent predictors of CAD were gender (male) (OR = 2.358; 95% CI; 1.543-3.601; p<0.001), duration of diabetes mellitus (years) (OR = 1.053; 95% CI; 1.024-1.083, p<0.001) and presence of neuropathy (OR = 1.590; 95% CI; 1.042-2.426, p=0.036). Conclusions: CCTA has a high positive predictive value (80.5%) to detect asymptomatic CAD in patients with type 2 diabetes. CCTA appeared to be useful screening tool for asymptomatic CAD in patients with type 2 diabetes, especially in male patients with long duration of diabetes mellitus and neuropathy.