Background: The safety and outcomes of percutaneous coronary interventions (PCI) in younger (��� 45 years) patients (pts) with significant coronary artery disease (CAD) in western population is available in the literature. But there are limited data regarding individual components of angiographic and major clinical outcomes in the Asian population in the drug-eluting stent (DES) era. Method: The study population consisted of 1734 consecutive pts who underwent PCI with DESs from April 2006 to August 2008. Six-month angiographic and 2-year clinical outcomes of younger (n=104 pts, 5.9%) pts were compared with those of elderly pts (n=1630 pts.94.1%). Results: Baseline characteristics were similar between the two groups except the younger pts had more males (95.2% vs. 63.8%, p=0.001), current smokers (60.6% vs. 28.7%, p <0.001) more likely to present with acute myocardial infarction (AMI,48.1% vs. 28.7%, p<0.001) and cardiogenic shock (8.7% vs.3.1%, p=0.008) but less hypertension (42.3% vs. 65.57%, p<0.001) and chronic renal insufficiency (4.8% vs. 11.2%, p=0.049). Although the mid-term angiographic outcomes were similar between the two groups, major clinical outcomes at 2-year including mortality, target lesion revascularization-major adverse cardiac events (TLR-MACE) and all MACEs were lower in the younger pts as compared with those of elderly pts in the multivariate analysis (Table). Conclusion: Younger CAD pts showed similar mid-term angiographic outcomes but showed better 2-year clinical outcomes including mortality, TLR MACE and all MACEs as compared with those of elderly pts in the DES era, suggestive of better prognosis of younger pts in general.