Background: It is unclear whether the routine follow up (FU) coronary angiography (CAG) regardless of patient���s symptoms at 6 to 9 months after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) in diabetic patients (pts) is beneficial or not. Methods: The study population consisted of 191 consecutive diabetic pts underwent PCI with DESs from November 2005 to June 2008. Routine FU CAG was performed between 6 to 9 months following index PCI and was decided by individual physician���s discretion. Pts died before 6 months were excluded in both groups. Cumulative clinical outcomes up to 2 years were compared between Routine CAG group (n=127 pts, 74.7%) and Clinical FU group (n= 64 pts, 37.6%). Results: A total 170 pts (89.0%) were finished 2-year clinical followed up. Baseline clinical and procedural characteristics were well balanced between the two groups except clinical FU group had lower left ventricular ejection fraction (LVEF). Pts in routine CAG group showed lower incidence of cardiac death up to 2 years without increasing Q-wave myocardial infarction (MI), repeat PCI and all major adverse cardiac events (MACEs, Table). Conclusions: In our study, routine CAG FU between 6 and 9 months after PCI with DESs in diabetic pts was associated with lower cardiac death without increasing repeat PCI due to oculostenotic reflex up to 2 years. We suggest that routine CAG FU may play an important role in reducing mortality of diabetic pts undergoing PCI with DESs.