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ǥ : ȣ - 540422   210 
The Impact of Abdominal Obesity on the Cardiac Structure and Function of Healthy Male Koreans: Atherosclerosis RIsk of Rural Area in koreaN General population (ARIRANG) study
연세대학교 원주의대¹ 유전체 코호트 연구소²
성중경¹, 김장영¹ ² , 고상백¹ ² , 윤영진¹ ² , 이준원¹ ², 안성균¹ ² , 유병수¹ ² , 이승환¹ ² , 윤정한¹ ² , 박종구¹ ² , 최경훈¹
Background and Objectives: Central obesity is a more powerful predictor to related cardiovascular risk factors and death than general obesity. However, few data are available for the effect of abdominal obesity to cardiac geometric and functional changes in a community-based study. Therefore, we evaluate the effect of abdominal obesity on the geometric and functional changes of the heart. And, we also aimed to investigate the relation of general and central obesity to the risk of these changes in healthy male Koreans. Subjecst and Methods: We enrolled consecutive 1,462 healthy male aged 40–70 year old from a community-based cohort. All subjects were performed anthropometric analysis and complete echocardiography examination including tissue Doppler imaging. Subjects were categorized into tertile group according to the waist circumference (WC). We defined LA enlargement (LV volume >58mL), LV enlargement (LA end diastolic dimension > 5.9cm) and LV hypertrophy ( LV mass > 50 g/m2.7) . Results: Mean age was 53.5 ± 7.8. Increasing tertile of WC had a stepwise larger LA volume, LV end-diastolic dimension, LV mass to height2.7, deceleration time of E wave, and lower E/A ratio (all p values <0.001). In multivariate regression model adjusted age, blood pressure, and glucose level, upper tertile of WC (>89cm) was independently associated with LA enlargement (OR 4.47, 95% CI 3.34-5.97), LV hypertrophy (OR 1.82, 95% CI 1.341-2.462), LV enlargement (OR 3.59, 95% CI 2.49-5.18) and diastolic dysfunction (OR 1.9, 95% CI 1.422-2.538). LV ejection fraction and relative wall thickness were not increased by increment of WC. After stratification of body mass index, the OR of LA enlargement, LV enlargement, and diastolic dysfunction were additive increased by increment tertile of WC. Conclusions: Abdominal obesity was independently associated with eccentric LV hypertrophy, diastolic dysfunction, and LA enlargement. Central obesity also has an additive effect on these changes within stratified general obesity.


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