Purposes:To assess coronary artery calcium (CAC) on cardiac CT and peak systolic flow velocity at the aortic valve (Vmax) on echocardiography as independent associated factors to aortic valve calcification (AVC) and to evaluate correlations among AVC, CAC, and Vmax. Materials and methods: Clinical data of 1,025 subjects (687 males, age 58.5짹10.2 years) who underwent both echocardiography and ECG-gated CT for routine annual medical examination without subjective symptoms were analyzed. The presence of AVC and CAC were determined by non-contrast cardiac computed tomography. The burden of AVC (CTavc) and coronary artery calcium score (CACS) were calculated. Peak systolic velocity at the aortic valve (Vmax) was measured using echocardiography. Significantly different factors between presence and absence of AVC were included for multivariate analysis. Independently associated factors with the presence of aortic valve calcification were determined. Correlations among CTavc, CACS, and Vmax were also evaluated. Results: The prevalence of AVC and CAC was 33.1% and 73.9%, respectively. Among those without CAC, the prevalence of AVC was 13% and increased across levels of CAC severity such that 25%, 46%, and 76% had AVC with increasing CACS group of 1-99, 100-399, and > or = 400, respectively (P for trend<0.0001). Vmax was 1.35 m/s without AVC and 1.54 m/s (P<0.001) with AVC. Age, CACS group and Vmax were the independently associated to the presence of AVC. The odds ratio of AVC among those with mild CAC (1-99) was 1.52 (95% CI, 0.957-2.427) and increased to 7.23 (95% CI, 3.96-13.20) for CAC > or = 400. CTavc and Vmax were significantly higher in the CACS group of > or = 400 compared with the group of 0. Odds ratio of AVC to Vmax was 4.725 (95% CI, 2.560-8.722). Correlation co-efficient was 0.560 between CTavc and Vmax (P<0.001), 0.172 between CTavc and log (CACS+1) (P<0.001), and 0.114 between Vmax and log (CACS+1) (P<0.001). Conclusions: AVC is independently associated with increasing severity of CAC and Vmax. Vmax is significantly correlated with CTavc and CACS. The results of this study imply that degenerative aortic valve stenosis is related with systemic atherosclerosis.