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ǥ : ȣ - 540522   61 
Long-term clinical outcomes comparing sirolimus-eluting (Cypher®) ) with paclitaxel-eluting (TaxusTM) stents : 5 year MACE
충남대학교 의전원, 충남 대학교 병원 심장내과, 대전충남권역심뇌혈관센터
신성균, 정진옥, 진선아, 박용규, 김준형, 박재형, 최시완, 성인환
Background; Cypher® sirolimus-eluting(SES) and TaxusTM paclitaxel-eluting stents(PES) are known to have similar clinical and angiographic outcomes. We analyzed all patients who received SES or PES retrospectively.
Methods; A total of 949 patients who underwent either SES or PES implantation in our hospital from January 2003 to December 2005, evaluated by medical records and vital statistics supplied by statistics Korea. Primary endpoint was a composite of all cause death, myocardial infarction, target lesion revascularization and target vessel revascularization during 5 years after the procedure.
Results: During 5 years after the procedures, the primary end point occurred in 248 cases(26.1%), where composite end point(SES 27.6% vs PES 20.2% p= 0.31) and all cause death(SES 16% vs PES 10.8%, p=0.04 ) were observed in SES and PES group respectively.
Conclusion; Despite higher rate of all cause death occurred in SES group, composite end point, MI, TLR, TVR were not significantly different between SES and PES group.

 

SES (n=663)

PES (n=286)

p-value

Age

63.4±10.9

63.5±10.4

ns

Male (%)

431 (65%)

188 (65.7%)

ns

DM (%)

191 (29.6%)

82 (29,7%)

ns

H/T (%)

335 (51.5%)

148 (53%)

ns

Smoking (%)

101 (15.6%)

29 (10.5%)

0.049

Hyperlipidemia

134 (20.8%)

56 (20.2%)

ns

Composite end point

(Death, MI, TLR, TVR),

183 (27.6%)

65 (22.7%)

0.31

All cause Death

106 (16.0%)

31 (10.8%)

0.038

MI

14 (2.1%)

5 (1.7%)

0.71

TLR

59 (8.9%)

28 (9.8%)

0.66

TVR

20 (3%)

7 (2.4%)

0.63



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