Background: The impact of antihypertensive therapy on dyssynchrony in patients with never-treated and uncomplicated hypertension has not been explored. Methods: Fourty two patients of never-treated and uncomplicated hypertension (47.6% men, mean age 55.6 짹 9.9 years) underwent echocardiographic evaluations of dyssynchrony at baseline and after 6 months of antihypertensive therapy. Measured parameters were as follows: i) standard deviation of time from ECG Q to systolic peak velocity of 12 Left ventricular (LV) segments (ms, Ts-SD12) and maximum difference of time to systolic peak velocity among 12 LV segments (ms, Ts-Max) (systolic dyssynchrony); (ii) sum of time exceeding aortic closure in strain curves of 12 LV segments (ms, oExcT) (contractile diastolic dyssynchrony); (iii) SD of time from ECG Q to early diastolic peak velocity of 12 LV segments (ms, Te-SD12) and maximum difference of time to early diastolic velocity among 12 LV segments (ms, Te-Max) (diastolic dyssynchrony). Ts-SD12 ���33ms or Ts-Max ���100ms was regarded as systolic dyssynchrony. Patients with systolic dyssynchrony (group 1, N=18) and without systolic dyssynchrony (group 2, N=24) at baseline were compared. Results: The echocardiographic parameters were summarized in the table. In group 1 patients, systolic (Ts-SD12, Ts-Max) and diastolic (Te-Max) dyssynchrony, and LV mass index (LVMI) significantly improved after antihypertensive therapy. However, there were no significant differences except oExcT in group 2 patients. Conclusions: Antihypertensive therapy could reverse the echocardiographic parameters of dyssynchrony in patients with hypertension and systolic dyssynchrony.