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ȣ - 540615 212 |
| Can ventricular-vascular coupling be a surrogate marker in the management of non-diabetic chronic kidney disease? |
| 가천의대 심장센터 심장내과¹ , 가천심혈관연구소² , 신장내과³ |
| 김의주¹, 정욱진¹² , 김세중³ , 성지윤³ , 신미승¹² , 이경훈¹² , 강웅철¹² , 한승환¹² , 고광곤¹² , 안태훈¹² , 최인석¹² , 신익균¹² |
Background and Objectives:
Ventricular-vascular coupling (VVC) was suggested that it means net afterload and also reflects total cardiovascular performance. Also estimated glomerular filtration rate (eGFR) was an essential functional parameter in chronic kidney disease (CKD). However, there was no report about the relationship between VVC and eGFR in CKD.
Subjects and Methods:
We performed cross-sectional study with 98 patients excluding overt cardiovascular disease, uncontrolled blood pressure, diabetes mellitus and anemia from January 2009 to December 2009. Systolic and diastolic ventricular function and VVC were assessed by transthoracic echocardiography. eGFR was calculated by the Modification of Diet in Renal Disease(MDRD) equation.
Results: The patients (54 ± 13.5 years, 59.2% male, 29.6% hypertensive) showed mild decreased mean eGFR ( 84.5 ± 15.1 ml/min/1.73m2). As we expected, VVC was negatively correlated with eGFR (β=-0.247, P = 0.014). After the adjustment of covariables such as age, gender, BSA, SBP, DBP, EF, E/E’, LVMI, LAVI, and Tei index, VVC was independently predicted by eGFR (β=-0.211, P = 0.004).
Conclusion: VVC was independently associated with eGFR in mild non-diabetic CKD patients. So, VVC may be an surrogate marker in management of mild non-diabetic CKD.
Keywords: Ventricular-vascular coupling, estimated GFR, chronic kidney disease
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