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The determination of the factors impacting on survival in patients with heart failure associated preserved LV systolic function in Korean Acute Heart Failure (KorHF) registry
충북대학교 병원 순환기 내과
김상민, 이상엽, 배장환, 황경국, 김동운, 조명찬
Background : Diastolic dysfunction and the clinical syndrome of diastolic heart failure (HF) have become well recognized largely due to increased recognition of diastolic mechanism as a cause for heart failure. But, the prognostic factors for diastolic heart failure were not still defined. Methods and Results : The Korean Heart Failure registry (KorHFR) prospectively studied the characteristic and outcomes in a broadly sampled patients hospitalized with worsening HF and the outcomes were followed by 50 university centers in South Korea. Of the total cohort of HF 3,200 patients, 678 patients (21.2%) with heart failure associated preserved left ventricular (LV) systolic function were analyzed. During follow up, all-cause mortality was 17.1%. (114 patients) We analyzed clinical characteristics and outcomes of diastolic heart failure patients. Univariate analysis revealed that predictors for survival were age > 65, anemia [female hemoglobin (Hb) <12.0g/dL, male Hb < 13.0g/dL by WHO definition], Systolic blood pressure < 100 mmHg, pH on initial arterial blood gas analysis < 7.2, Sodium <130 mEq/L, and NT-proBNP > 400 pg/ml. On multivariate analysis, age (HR 1.747, 95% CI 1.079-2.830, p=0.023), anemia (HR 1.909, 95% CI 1.226-2.973, p=0.004), systolic blood pressure (HR 1.792, 95% CI 1.229-2.613, p=0.002) remained as independent predictors. Conclusions: In patients with HF associated preserved LV systolic function, age, anemia and systolic blood pressure were helpful to predict the prognosis in KorHFR. Key Words: Diastolic heart failure; Prognosis; Anemia; Systolic blood pressure


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