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Discrepency of mitral inflow pattern and early transmitral flow velocity (E)/early diastolic velocity of mitral annulus (E′) ratio for evaluation of diastolic dysfunction
대구가톨릭대학교 의과대학 순환기내과¹, 김천제일병원 순환기내과², 포항성모병원 순환기내과³
김정현², 정진욱³ , 이진배¹ , 성명준¹ , 이영수¹ , 류재근¹ , 최지용¹ , 김기식¹ , 장성국¹
Objective: Classfication of diastolic filling usually is classified on the basis of the peak mitral flow velocity of early rapid filling wave (E), peak velocity of the early rapid filling wave, and the E/A ratio, deceleration time (DT). However, early transmitral flow velocity (E)/early diastolic velocity of mitral annulus (E) correlated well with LV end-diastolic pressure. This study was designed to compare classic diastolic filling patten and E/E’ and that’s correlation of left atrial volume index (LAVI). Method: 3547 consecutive inpatients admitted to cardioloty department from May 1, 2006, to April 30, 2009 were included. Mitral inflow was assessed in a standard manner, E, A and DT were measured. Doppler tissue imaging of the mitral annulus was obtained from the apical 4-chamber view using a 1-2 mm sample volume placed in the septal and lateral mitral valve annulus. Early (E′) and late (A') annulus velocities were measured in both sites and acquired data were averaged. LA volume index was evaluated. Results: There are significant discrepency between classic mitral filling pattern and E/E. Only 34% of normal filling was normal E/E’ range and 26.3% of restrictive filling was normal E/E’. LAVI is increasing with increasing E/E’ grade but classic filling pattenrn grade is no cosistancy with LAVI increase. Conclusion: E/E’ ratio allowed the identification of patient with diastolic heart failure more accurately than classic diastolic filling pattern.

Parameter, n (%)

E/E’<8

8E/E’<15

E/E’15

Normal

168(34.8)

250(51.8)

65(13.5)

Impared relaxation

239(10.2)

1303(55.6)

803(34.2)

Pseudonormal

40(6.2)

339(52.7)

264(41.1)

Restrictive

20(26.3)

40(52.6)

16(21.1)

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