Background: Reperfusion injury often occurs during coronary artery bypass graft (CABG) surgery due to excessive production of oxygen radicals. Coenzyme Q10 has been known to attenuate oxidative stress response. Objective: The objective was to examine the effect of coenzyme Q10 on hemodynamics in patients receiving CABG through a systemic review with controlled trials in humans. Methods: A systematic search of MEDLINE, CINAHL, and the Cochrane Central Register of controlled trials was conducted to identify controlled trials in humans evaluating coenzyme Q10's effect on hemodynamics with CABG. All databases were searched from their inception through December, 2008, using the key words coenzyme Q10, coenzyme Q, ubiquinone, ubidecarenone, Co Q10, CABG, open heat surgery, cardiothoracic surgery, cardiac surgery. A manual search of published literature was used to identify additional relevant studies. To be included in the analysis, studies must have been written in English and reported endpoints of hemodynamic parameters. A random-effects model was used to calculate the weighted mean difference(WMD) and 95% confidence intervals(CI) as the difference between the mean for the coenzyme Q10 and control groups. Standard methods for assessing statistical heterogeneity were used. Results: Three trials met the inclusion criteria. Coenzyme Q10 significantly reduced heart rate [WMD: 1.7 beats per minute; 95% CI -2.3 to -1.2] compared to control while mean arterial pressure change did not reach statistical significance [WMD: 8.1mmHg; 95% CI -8.3 to 24.5] between the coenzyme Q10 and control groups. There was only a minor degree of heterogeneity in the analyses. Conclusion: This systemic review suggests that coenzyme Q10 is associated with favorable effects on hemodynamic parameters in patients after CABG surgery. Future research should focus on the impact of coenzyme Q10 on clinical events in patient with CABG surgery.