Background: Stress-related cardiomyopathy (SRCMP) can occur after acute mental or physical stress, intracranial events, acute medical illness and during pheochromocytoma crisis. Associated complications of SRCMP are uncommon but it included hemodynamic instability, arrhythmias, heart failure, and cardiogenic shock are known to be uncommon. We studied the characteristics of complicated SRCMP in Korean population. Methods: During a 7-year period (2004-2010), 155 patients were clinically diagnosed as stress-related cardiomyopathy. The 155 patients (mean age 64.3짹13.9 yrs, female 76.1%) who fulfilled the following criteria: 1) regional wall motional abnormalities (WMA) in ventricle, 2) absence of obstructive coronary disease corresponding to region of WMA and 3) absence of known myocardiopathies. The significant complications were defined as cardiogenic shock, arrhythmia, heart failure, vascular events and the use of mechanical ventilation. Results: 90 patients (58.1%) had significant complications. 60 patients had experienced symptomatic heart failure and 39 patients had experienced cardiogenic shock. The arrhythmia was developed in 14 patients. There was no definite cardiac death. The patients with significant complications had significantly lower left ventricular ejection (LVEF) was independently associated with significant complications. and higher high-sensitivity C-reactive protein. In multivariate analysis after traditional cardiovascular risk factors, Conclusions: In our study, significant complications of SRCMP was not uncommon in Korean population. It might be associated with LVEF.