Backgroud : Transradial intervention (TRI) is drastically increasing because of the lower incidence of major bleeding and vascular complications. However, there have been very limited data regarding clinical outcomes according to left versus right radial access transradial intervention in Asian population. Methods: A total 2639 consecutive patients (pts) of seven major hospitals were enrolled from January to December 2009. In-hospital complications and cumulative clinical outcomes up to six months were compared between left radial access group (n=858, 32.5%) and right radial access group (n=1781, 67.4%). Results: Baseline characteristics showed that left radial access group were elderly, higher incidence of dyslipidemia, diabetes mellitus, prior CVD and higher left ventricular EF compared with those of right access group. In-hospital complications showed that left radial access group had lower incidence of CVD and transfusion. In-hospital and clinical outcomes up to six months showed TLR &TVR and MACEs were lower in the left radial access group (Table). Multivariate analysis showed that left radial access was an independent predictor of TVR (Adjusted OR: 36.01, 95% CI: 4.880-265.735, p-value<0.001) and TVR-MACE (Adjusted OR: 3.991 95% CI: 2.218-7.181, p-value=0.001) at 6 months. Conclusions: In our study, left radial access group in pts undergoing TRI with DESs was associated with lower in-hospital complications and better 6 months clinical outcomes as compared with those of right radial access group.