Background The level of the N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is known to be a strong predictor of mortality among patients with acute coronary syndromes. However, it remains elusive whether it can be a prognostic marker in patients with chronic stable coronary artery disease. We investigated the association of preprocedural NT-pro-BNP level and clinical outcomes in stable angina patients with normal left ventricle(LV) systolic function after percutaneous coronary intervention(PCI) Methods A total of 1,285 patients (mean age = 64.15 짹 9.89 yrs; male = 755 (58.8%) who underwent PCI with stable angina was analyzed retrospectively in catholic registry study. We excluded the patients with LV ejection fraction less than 50 % or renal dysfunction (serum creatinine >2.0 mg/dL). NT-pro-BNP was measured on admission prior to PCI. We compared MACE incidence between 4 groups divided by the 25% percentile level of NT-pro-BNP. Results Among baseline characteristics, the patients with highest quartile of NT-pro BNP level were older, more prevalent of female gender, hypertension and multivessel disease. They also had higher BMI, serum creatinine, fasting glucose level and hs-CRP but lower hemoglobin compared with the patients with lowest quartile of NT-pro BNP. On multivariate analysis, the patients with highest quartile of NT-pro BNP was not significantly associated with increased risk of MACE (death from any casue, MI, stroke, TLR and TVR) compared with those with lowest quartile (p=0.458, adjusted odds ratio, 0.837(95% CI, 0.523-1.339)). Conclusions Differing from acute coronary syndrome, preprocedural NT-pro-BNP levels does not show the role as a predictor of clinical outcomes after PCI in stable angina with preserved LV systolic function.