Objective: The objective of this study is to analyze long-term survival of the subjects with peripheral artery disease (PAD), and coronary artery disease (CAD). Methods: The sample included 4,526 Korean patients aged ���45 years who were hospitalized from 1994 through 2004. 405 subjects had PAD confirmed by computed tomography angiography, while 3,475 subjects had CAD confirmed by cardiac catheterization in Cardiac & Vascular Center, Samsung Medical Center. Mortality data were obtained from all participants between 1994 and 2009 from the Statistics Korea. All-cause mortality was measured upto 15 years. Results: The mean age (years) of PAD subjects was 65.1 (짹8.4) and that of CAD subjects was 62.4 (짹8.7) (p<0.001). For age group, 45 to 64 year-old group was 45.2% in PAD and 59.6 % in CAD. The proportion of males was 90.4% for PAD and 70.1% for CAD subjects (p<0.001). During the 5 to 15 years follow-up, all-cause cumulative mortality rate were 31.8% in PAD (29.1% without CAD in PAD and 36.8% with CAD in PAD) and 28.2% in CAD. The mean survival time was 8.77 (짹0.24) years in PAD and 11.4 (짹0.88) years in CAD. The mean survival time of PAD patients with coexisting CAD was 8.86 (짹0.28) years and that without coexisting CAD was 8.32 (짹0.42) years (p=NS) (Fig). Ten years survival rate was 59% in PAD and 71% in CAD. The independent predictors of mortality were included, but not limited to, age, diabetes, and chronic kidney disease (CKD) in PAD and age, male gender, diabetes, dyslipidemia, smoking, CKD and anemia in CAD. Interestingly, overweight and obesity showed lower hazard ratio in PAD or CAD group. Conclusion: In this study, we found that cardiovascular risk factors contributed to mortality. It seems that there is no difference in mortality rate with or without coexisting CAD in PAD. However, it seems that there is no similarity between PAD and CAD for their mortality rate.