Purpose We aimed to investigate predictive value of high sensitivity C-reactive protein (hsCRP) in predicting cardiovascular events in asymptomatic population. Methods A total of 4,690 patients who had coronary computed tomography (CT) angiography between 2006 and 2008 were evaluated. Cardiovascular (CV) events were defined as acute coronary syndrome, stroke or cardiovascular deaths Results The patients were followed for 920 days, during which 40 patients experienced CV events. The prognosis showed significant difference according to plaque characters (Figure 1A, p<0.001) and level of hsCRP. In patients without plaque, hsCRP did not show any predictive power. (p=0.712) Whereas patients with non-calcified plaque (NCP) showed different event-free survival according to hsCRP, patients with calcified or mixed plaque did not show significant difference (Figure 1B), when adjusted for Framingham risk score and coronary artery calcium score. From multivariate model (Table), hsCRP >2mg/L was a strong predictor of cardiovascular events in patients with presence of NCP (p=0.017, Exp(B)=3.37, 95%CI 1.24-9.13), whereas in patients without NCP, hsCRP did not have significant predictive value (p=0.106). Conclusion Elevated hsCRP is an independent predictor of adverse CV events in asymptomatic patients with NCP.