ABSTRACT Background and Objectives: Diabetes mellitus (DM) is a strong risk factor of cardiovascular disease. Guidelines recommended that hemoglobin (Hb) A1c should be lowered less than 7.0%. Type 2 diabetic patients have increased arterial stiffness and are augmented risk for cardiovascular morbidity and mortality. We evaluated the effect of long-term glucose control on arterial stiffness, assessed by pulse wave velocity (PWV), in type 2 DM patients with coronary artery disease. Subjects and Methods: 187 type 2 DM patients who underwent PCI were retrospectively reviewed. Arterial stiffness was assessed by brachio-ankle PWV measurement. We stratified the patients according to 12-month HbA1c 7.0%, and compared clinical and PWV data. Statistics included multivariate linear regression to investigate the independent correlates for the changes of PWV. Results: The incidence of in-stent restenosis was higher in patients with 12-month HbA1c ���7.0% than those with <7.0% (16.7 vs. 5.5%, p=0.013). The patients with 12-month <7.0% revealed significantly reduced PWV (1511.3 짹 279.3 ��� 1450.9 짹 243.1 cm/s, p=0.013) than those with ���7.0% (1606.2 짹 358.5 ��� 1634.8 짹 360.7 cm/s, p=0.403). However, this beneficial effect was diminished in patients with high baseline HbA1c. The glucose control statue was significantly correlated with changes of PWV (r = 0.286, p = <0.001). Multivariate analysis revealed that HbA1c, serum creatinine, systolic blood pressure, heart rate, and body mass index were independent predictors for the changes of PWV. Conclusion: In type 2 DM patients, glucose control was associated with the changes of PWV.