Background: Patients (pts) with diabetes mellitus (DM) are at increased risk of restenosis and other adverse cardiac events following percutaneous coronary intervention (PCI). However, there have been limited data regarding the impact of DM on major clinical outcomes following chronic total occlusion (CTO) intervention with drug-eluting stents (DESs). Methods: A total 277 consecutive pts who underwent PCI with DESs for CTO lesions were enrolled for the study. Study population was divided into 2 groups; diabetic (n=93) and non-diabetics (n=184). Baseline clinical characteristics, procedure related complications and mid-term clinical outcomes were compared between the two groups. Results: Baseline clinical characteristics were similar except that non-diabetics group had more males (70.0% vs.67.7%, p=0.041), whereas diabetics had more hypertension (73.1% vs.56.8%, p=0.008). No difference was found in procedure related complications & one year major clinical outcomes between the two groups (Table). Conclusions: Regarding the CTO intervention outcomes following PCI with DESs, there was no significant difference between diabetics and non-diabetics in procedure related complications and one year cumulative clinical outcomes.