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ȣ - 550259 122 |
| Could Mean Platelet Volume be a Predictive Marker for One Year Clinical Outcomes in Patients Underwent Percutaneous Coronary Intervention? |
| 고려대학교 구로병원 심혈관 센터 |
| 최철웅, Amro Elnagar, 김선원, 임성일, 나진오, 임홍의, 김진원, 김응주, 한성우, 나승운, 박창규, 서홍석, 오동주 |
Backgrounds: Mean platelet volume (MPV) is one of the platelet function indices which reflects the platelet production rate and stimulation. The aim of this study is to evaluate the impact of MPV on one year clinical outcomes in patients underwent percutaneous coronary intervention (PCI).
Methods: A total 1215 patients (Age; 63.43 ± 11.55, Men; 66.3 %) underwent PCI were enrolled. We examined the MPV before coronary angiogram. We evaluated the relation between MPV and major adverse cardiac events (MACEs)
Results:One year after PCI, 138 MACEs were developed. MPV was higher in MACEs group compared with that in Non-MACEs group (respectively, 8.70± 1.34 fl vs. 8.38± 1.26 fl, p = 0.009) In multivariate analysis, MPV was a independent predictor for one year MACEs (OR; 1.187, p=0.050).
Conclusion:This study identified high MPV as an independent risk factor for one year MACEs in patients who underwent PCI.
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Table . Odds ratios of risk factors for 12 Month MACEs.
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univariate analysis |
p |
multivariate analysis |
p |
|
Age |
1.039(1.022-1.057) |
<0.001 |
1.033(1.012-1.054) |
0.002 |
|
LV EF |
0.966(0.951-0.982) |
<0.001 |
0.978(0.956-1.000) |
0.048 |
|
DM |
1.575(1.093-2.271) |
0.015 |
1.446(0.929-2.250) |
0.102 |
|
MPV |
1.214(1.058-1.392) |
0.006 |
1.187(1.000-1.410) |
0.050 |
|
Cr |
3.068 (1.550-6.074) |
0.001 |
1.273(0.507-3.197) |
0.608 |
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LM |
1.986 (1.122-3.513) |
0.018 |
1.680(0.849-3.325) |
0.137 |
|
AMI |
1.710 (1.191-2.455) |
0.004 |
1.070(0.638-1.795) |
0.797 |
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HsCRP |
1.013(1.008-1.018) |
<0.001 |
1.008(1.002-1.014) |
0.007 |
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